While Agave plants are not necessarily toxic to humans or animals, they do have sharp spines along the edges of their leaves that can cause injury. Additionally, the sap from some species of Agave can cause skin irritation or allergic reactions in some people. Ingesting large quantities of the plant or its sap can also cause gastrointestinal upset. Finally, while the Agave is not inherently dangerous, it is important to note that it is a popular ingredient in tequila and other alcoholic beverages, which can be harmful to consume in excess.