No, the African Mask itself is not poisonous and should not pose any danger to humans or animals. However, some masks may have been treated with chemicals or paints that could be toxic if handled or ingested, so it is important to use caution and seek expert advice before handling old or antique masks. Additionally, some masks may have cultural and spiritual significance to the communities that created them, so it is important to treat them with respect and follow any guidelines or customs associated with them.