The Boneset plant is not poisonous to humans or animals. However, it is recommended to consult with a healthcare professional before consuming Boneset as a herbal remedy, as it can cause side effects such as nausea, vomiting, and diarrhea. Additionally, high doses of Boneset may be toxic and cause liver damage. As with any herbal remedy, it is important to use caution and consult with a healthcare provider before use.